Asian Journal of Research in Chemistry

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New Simple UV Spectrophotometric Method for Estimation of Almotriptan Malate in Bulk and Pharmaceutical Dosage Forms


Affiliations
1 Department of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur-522002, India
2 Department of Chemistry/Pharmacy, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur-522510, India
     

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A new simple, sensitive, precise, accurate and economical UV spectrophotometric method of analysis for almotriptan malate both as a bulk drug and in tablet formulations was developed and validated. The method employed methanol as solvent and the drug shows maximum absorbance at 227 nm with molar absorptivity of 0.8532×105 L/mol.cm. The linear regression analysis data for the calibration plot showed good linear relationship with r2=0.9999 in the concentration range of 1-5 μg/ml. Results of analysis were validated statistically and by recovery studies.

Keywords

Almotriptan Malate, U.V Spectrophotometry, Tablets.
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  • New Simple UV Spectrophotometric Method for Estimation of Almotriptan Malate in Bulk and Pharmaceutical Dosage Forms

Abstract Views: 269  |  PDF Views: 0

Authors

A. Suneetha
Department of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur-522002, India
B. Syama Sundar
Department of Chemistry/Pharmacy, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur-522510, India

Abstract


A new simple, sensitive, precise, accurate and economical UV spectrophotometric method of analysis for almotriptan malate both as a bulk drug and in tablet formulations was developed and validated. The method employed methanol as solvent and the drug shows maximum absorbance at 227 nm with molar absorptivity of 0.8532×105 L/mol.cm. The linear regression analysis data for the calibration plot showed good linear relationship with r2=0.9999 in the concentration range of 1-5 μg/ml. Results of analysis were validated statistically and by recovery studies.

Keywords


Almotriptan Malate, U.V Spectrophotometry, Tablets.