A Study of Postinfectious Glomerulonephritis in Adults

Introduction: To study the clinical presentation and outcome of postinfectious glomerulonephritis in adults.

Materials and Method: This was a prospective study of 50 cases of post-infectious glomerulonephritis. All patients were followed up for 18 months. The mode of presentation, history of sore throat or skin infections were documented. Serum creatine, Urinary proteinuria, C3 level, and ASO titre were performed.All these patients were followed up every two weeks after discharge for six months and four weekly thereafter for one year. Outcomes were classified as complete remission, partial remission and development of end stage renal disease.

Results: In their presentation to the hospital Oedema was present in 98% of the cases. 84% of patients had oliguria, Gross haematuria was present in 24% of patients and hypertension was present in 92% of the patients. ASO titre was positive in 16% of the patients. Most patients (82%) had proteinuria between 2.5-3.5 gm/24hrs. Complete remission was achieved in 84% of the patients. Partial remission in 12% of the cases and 4% of the patients went on to develop end stage renal disease (ESRD). The presence of gross haematuria and nephrotic range proteinuria correlated with the development of end stage renal disease

Conclusion: Gross haematuria, nephrotic proteinuria, impaired renal function and presence of crescents in kidney biopsy at intial presentation are poor prognostic indicators of post-infectious glomerulonephritis in adults.