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The Role of Levosimendan in Acute Aluminum Phosphide Induced Myocardial Toxicity
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Acute aluminum phosphide poisoning (AAlPP) or celphos is one of the most commonly used poisons for suicidal purpose. Number of cases reported to the hospital represents only the tip of an iceberg. Most of the patients succumb to this poison due to inadequate or lack of treatment. In our case, we added levosimendan to the already established treatment guidelines for AAlPP poisoning and we got surprising result as we could discharge the patient from our Intensive Care Unit in just 2 days with all vitals stable.
Keywords
Aluminum Phosphide, Celphos, Levosimendan, Toxicology.
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- Chugh SN, Dushyant K, Ram S, Arora B, Malhotra KC. Incidence and outcome of aluminium phosphide poisoning in a hospital study. Indian J Med Res. 1991; 94:232–5.
- Mathai A, Bhanu MS. Acute aluminium phosphide poisoning: Can we predict mortality? Indian J Anaesth. 2010; 54:302–7.
- Papp Z, Edes I, Fruhwald S, De Hert SG, Salmenpera M,Leppikangas H et al. Levosimendan: Molecular mechanisms andclinical implications: consensus of experts on the mechanisms of action of levosimendan. Int J Cardiol. 2012; 159:82–7.
- Gurjar M, Baronia AK, Azim A, Sharma K. Managing aluminum phosphide poisonings. J Emerg Trauma Shock. 2011; 4:378–84.
- Ranga GS, Dwivedi S, Agarwal M, Kumar D. Aluminium phosphidepoisoning in a young adult: A suicidal cardiotoxin simulating myocardial ischaemia. J Indian Acad Clin Med. 2004; 5:369.
- Moghadamnia AA. An update on toxicology of aluminum phosphide. DARU J Pharm Sci. 2012; 20:25.
- Shadnia S, Rahimi M, Pajoumand A, Rasouli MH, Abdollahi M. Successful treatment of acute aluminium phosphide poisoning: Possible benefit of coconut oil. Hum Exp Toxicol. 2005; 24:215–8.
- Siwach SB, Singh P, Ahlawat S, Dua A, Sharma D. Serum and tissue magnesium content in patients of aluminium phosphide poisoning and critical evaluation of high dose magnesium sulphate therapy in reducing mortality. J Assoc Physicians India. 1994; 42:107–10.
- Chaudhry D, Rai AS. N‑acetyl cysteine in aluminum phosphide poisoning: Myth or hope. Indian J Crit Care Med. 2014; 18:646–7.
- Wahab A, Zaheer MS, Wahab S, Khan RA. Acute aluminium phosphide poisoning: An update. Hong Kong J Emerg Med.2008; 15:152–5.
- Graudins A, Najafi J, Rur SC MP. Treatment of experimental verapamil poisoning with levosimendan utilizing a rodent model of drug toxicity. Clin Toxicol (Phila). 2008; 46:50–6.
- Janssen PM, Datz N, Zeitz O, Hasenfuss G. Levosimendan improves diastolic and systolic function in failing human myocardium. Eur J Pharmacol. 2000; 404:191–9.
- Hasenfuss G, Pieske B, Castell M, Kretschmann B, Maier LS, Just H. Influence of the novel inotropic agent levosimendan on isometrictension and calcium cycling in failing human myocardium. Circulation. 1998; 98:2141–7.
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