Toxicology International (Formerly Indian Journal of Toxicology)

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Study of Cadmium and Chlorpyrifos Induced Changes in Protein and Lipid Profile in Rats


Affiliations
1 Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telangana, India
2 Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Korutla, Jagtial District, Telangana – 505326, Telangana, India
3 Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telengana, India
     

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The present work was aimed to know the changes in protein and lipid profile induced cadmium and chlorpyrifos Wistar rats. Work was carried out for 28 days in rats. 1: Control. 2: CdCl2 @ 22.5 mg/kg b.wt/oral. 3: CPF @ 25 mg/kg b.wt/per oral. 4: CdCl2@22.5 mg + CPF @ 25 mg/kg b.wt/per oral. Results revealed a significant (P<0.05) decrease in the concentration of total protein and albumin in Groups 2, 3 and 4 and also a significant (P<0.05) increase in total cholesterol, triglycerides and phospholipids in Groups 2, 3 and 4 on 15th and 29th day of the experiment. The adverse changes in protein and lipid profile in combined Group were severe than individual Groups due to synergistic action of the combined pollutants.

Keywords

Cadmium, Chlorpyrifos, Lipid Profile, Protein Profile, Wistar Rats.
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  • Calderoni AM, Oliveros L, Jahn G, Anton R, Luco J and Gimenez. MS. Alterations in the lipid content of pituitary gland and serum prolactin and growth hormone in cadmium treated rats. Biometals. 2015; 18: 213–20. PMid: 15984566. https://doi.org/10.1007/s10534-005-0581-4

  • Poulsen BM, Andersen HR, Grandjean P. Potential developmental neurotoxicity of pesticides used in Europe. J Environ Health. 2008; 7:50. PMid: 18945337 PMCid:

  • PMC2577708. https://doi.org/10.1186/1476-069X-7-50 3. Limei Z, Xiaoyong L, Tongbin C, Xiulan,Y, Hua X, Bin W, Lixia W. Regional assessment of cadmium pollution in agricultural lands and the potential health risk related to intensive mining activities: A case study in Chenzhou City. J Environ Sci China. 2008; 20(6):696–703. https://doi. org/10.1016/S1001-0742(08)62115-4

  • Yadala R, Madhuri D, Lakshman M, Gopala Reddy A, Kalakumar B. Haematological alterations induced by Cadmium (Cd) and Chlorpyrifos (CPF) in Male Wistar albino Rats. Int J Curr Microbiol App Sci. 2019; 8(08):480– 5. https://doi.org/10.20546/ijcmas.2019.808.055

  • Henson MC, Chedrese PJ. Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction. Exp Biol Med. 2004; 229(5):383–92. PMid: 15096650. https://doi. org/10.1177/153537020422900506

  • Idris SB, Ambali SF, Ayo JO. Cytotoxicity of chlopyrifos and cypermethrin: The ameliorative effects of antioxidants. Afr J Biotechnol. 2012; 11(99):16461–7.

  • Curcic M, Sasa J, Vesna J, Sanja V, Slavika V, Ksenija D, Zorica B, Biljana A. Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats. Arh Hig Rada Toksikol, 2012; 63:255–62. PMid: 23152375. https://doi.org/10.2478/10004-1254-63-2012- 2179

  • Randa AH, Dawlat MA, Nariman AR, Hatem ME, Dessouky MI. Clinicopathological, histopathological and immunological studies on animals exposed to lead and cadmium under experimental conditions. N Y Sci J. 2012; 5:12.

  • Yongfeng Deng Y, Zhang Y, Lu Y, Zhao Y, Ren H. Hepatotoxicity and nephrotoxicity induced by the chlorpyrifos and chlorpyrifos-methyl metabolite, 3,5,6-trichloro-2-pyridinol, in orally exposed mice. Sci Total Environ. 2016; 544:507–14. PMid: 26674679. https://doi.org/10.1016/j.scitotenv.2015.11.162

  • Manna P, Sinha M, Sil P. Amelioration of cadmium-induced cardiac impairment by taurine. Chem Biol Interact. 2008; 174(2):88–97. PMid: 18561905. https://doi.org/10.1016/j. cbi.2008.05.005

  • Bharathi P, Gopala Reddy A, Rajasekher Reddy A, Alpharaj M. A study of certain herbs against chlorpyrifos-induced changes in lipid and protein profile in poultry. Toxicol Int. 2010; 18(1):44–6. PMid: 21430920 PMCid: PMC3052583. https://doi.org/10.4103/0971-6580.75854

  • Snedecor GW, Cochran WG. Statistical methods, 8th ed. IOWA State University Press: Amer, IOWA, USA; 1994. p. 217–68.

  • Tomaszewska E, Winiarska-Mieczan A, Dobrowolski P. Hematological and serum biochemical parameters of blood in adolescent rats and histomorphological changes in the jejunal epithelium and liver after chronic exposure to cadmium and lead in the case of supplementation with green tea vs black, red or white tea. Exp Toxicol Pathol. 2015; 67(5):331–9. PMid: 25837382. https://doi. org/10.1016/j.etp.2015.02.005

  • Babaknejad N, Moshtaghie AA, Shahanipour K, Bahrami S. The protective roles of zinc and magnesium in cadmiuminduced renal toxicity in male Wistar rats. Iran J Toxicol. 2015; 8(27):1160–7.

  • Ambali S, Joseph O, King A, Esievo N, Samuel A. Hemotoxicity induced by chronic chlorpyrifos exposure in Wistar rats: Mitigating effect of Vitamin C. Vet Med Int. 2010; 1–7. PMid: 21647348 PMCid: PMC3103876. https://doi. org/10.4061/2011/945439

  • Barski D, Spodniewska A. Effect of chlorpyrifos and enrofloxacin on selected enzymes in rats. Pol J Vet Sci. 2018; 21(1):39–46..


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  • Study of Cadmium and Chlorpyrifos Induced Changes in Protein and Lipid Profile in Rats

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Authors

Y. Ravikumar
Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telangana, India
D. Madhuri
Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telangana, India
M. Lakshman
Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telangana, India
A. Gopala Reddy
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Korutla, Jagtial District, Telangana – 505326, Telangana, India
B. Kalakumar
Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telengana, India

Abstract


The present work was aimed to know the changes in protein and lipid profile induced cadmium and chlorpyrifos Wistar rats. Work was carried out for 28 days in rats. 1: Control. 2: CdCl2 @ 22.5 mg/kg b.wt/oral. 3: CPF @ 25 mg/kg b.wt/per oral. 4: CdCl2@22.5 mg + CPF @ 25 mg/kg b.wt/per oral. Results revealed a significant (P<0.05) decrease in the concentration of total protein and albumin in Groups 2, 3 and 4 and also a significant (P<0.05) increase in total cholesterol, triglycerides and phospholipids in Groups 2, 3 and 4 on 15th and 29th day of the experiment. The adverse changes in protein and lipid profile in combined Group were severe than individual Groups due to synergistic action of the combined pollutants.

Keywords


Cadmium, Chlorpyrifos, Lipid Profile, Protein Profile, Wistar Rats.

References





DOI: https://doi.org/10.18311/ti%2F2020%2Fv27i1%262%2F25279