Asian Journal of Pharmaceutical Analysis

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Novel Colorimetric Methods for Quantitative Estimation of Diacerin from Capsule Formulation


Affiliations
1 PRIST University, Thanjavur, Tamilnadu, India
2 Pacific College of Pharmacy, Debari, Udaipur (Rajasthan) 313003, India
3 P.Wadhwani College of Pharmacy, Yavatmal, Maharahtra, India
     

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Two simple and sensitive colorimetric methods have been developed for the quantitative estimation of Diacerin from Pharmaceutical Capsule dosage form. Developed methods are based on the formation of chloroform extractable ion pair coloured complex of drug with Orange II (Method A) and Tropoelin (Method B). The complex formed in method A and B showed maximum absorbance at 435. Linearity was obeyed in concentration range of 50-350 μgm/ml and 50-250 μgm/ml of Diacerin for method A and B respectively. The results of analysis were validated statistically and by recovery studies.

Keywords

Diacerin, Orange II, Tropoelin, Colorimetric Method
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  • Novel Colorimetric Methods for Quantitative Estimation of Diacerin from Capsule Formulation

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Authors

Sanjay Bais
PRIST University, Thanjavur, Tamilnadu, India
Indrajeet Singhvi
Pacific College of Pharmacy, Debari, Udaipur (Rajasthan) 313003, India
Anil Chandewar
P.Wadhwani College of Pharmacy, Yavatmal, Maharahtra, India
Mrunal Shirsat
Pacific College of Pharmacy, Debari, Udaipur (Rajasthan) 313003, India

Abstract


Two simple and sensitive colorimetric methods have been developed for the quantitative estimation of Diacerin from Pharmaceutical Capsule dosage form. Developed methods are based on the formation of chloroform extractable ion pair coloured complex of drug with Orange II (Method A) and Tropoelin (Method B). The complex formed in method A and B showed maximum absorbance at 435. Linearity was obeyed in concentration range of 50-350 μgm/ml and 50-250 μgm/ml of Diacerin for method A and B respectively. The results of analysis were validated statistically and by recovery studies.

Keywords


Diacerin, Orange II, Tropoelin, Colorimetric Method

References