Asian Journal of Research in Chemistry

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Synthesis, Analgesic and Anti-Inflammatory Activities of Novel Schiff Bases of 2-Amino-5-Aryl-1, 3, 4-Thiadiazole


Affiliations
1 Department of Pharmaceutical Chemistry, Nandha College of Pharmacy and Research Institute, Erode-52, Tamilnandu, India
2 Institute of Pharmacy, RITEE, Mandir Hasaud, Chhatauna, Raipur - 492101 (C.G.), India
     

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Schiff Bases of 2-amino-5-aryl-1, 3, 4-thiadiazole derivatives have been synthesized with different aromatic aldehyde. 1, 3, 4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde. The structures of the titled Schiff bases were elucidated by IR and 1H NMR spectral measurements. All the compounds were evaluated for their analgesic activity against Swiss albino mice, anti-inflammatory activity against Wister albino rats.


Keywords

Schiff base, 1, 3, 4-Thiadiazole, Analgesic, Anti-Inflammatory Activity.
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  • Synthesis, Analgesic and Anti-Inflammatory Activities of Novel Schiff Bases of 2-Amino-5-Aryl-1, 3, 4-Thiadiazole

Abstract Views: 317  |  PDF Views: 2

Authors

Alok Pandey
Department of Pharmaceutical Chemistry, Nandha College of Pharmacy and Research Institute, Erode-52, Tamilnandu, India
Shekhar Verma
Institute of Pharmacy, RITEE, Mandir Hasaud, Chhatauna, Raipur - 492101 (C.G.), India
Ravindra Dhar Dubey
Institute of Pharmacy, RITEE, Mandir Hasaud, Chhatauna, Raipur - 492101 (C.G.), India
Dhansay Dewangan
Department of Pharmaceutical Chemistry, Nandha College of Pharmacy and Research Institute, Erode-52, Tamilnandu, India
Vidyanand Patel
Institute of Pharmacy, RITEE, Mandir Hasaud, Chhatauna, Raipur - 492101 (C.G.), India
Keshav Deshmukh
Institute of Pharmacy, RITEE, Mandir Hasaud, Chhatauna, Raipur - 492101 (C.G.), India

Abstract


Schiff Bases of 2-amino-5-aryl-1, 3, 4-thiadiazole derivatives have been synthesized with different aromatic aldehyde. 1, 3, 4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde. The structures of the titled Schiff bases were elucidated by IR and 1H NMR spectral measurements. All the compounds were evaluated for their analgesic activity against Swiss albino mice, anti-inflammatory activity against Wister albino rats.


Keywords


Schiff base, 1, 3, 4-Thiadiazole, Analgesic, Anti-Inflammatory Activity.