Asian Journal of Research in Chemistry

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Synthesis and Antioxidant Potential of Novel 2-Isoxazole Substituted Chromenones Synthesized by Microwave Irradiation


Affiliations
1 Pharmacy Group, Birla Institute of Technology and Science, Pilani-333031, Rajasthan, India
     

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Novel series of substituted 2-[3-(2,6-halophenyl)-5-methyl-isoxazolyl]-chromen-4-ones were synthesized by microwave irradiation method. The antioxidant activity of the synthesized compounds 5a-j was evaluated using free radical scavenging method (DPPH method) and reducing power assay. The antioxidant activity of synthesized chromenones with respect to the standard used, ascorbic acid is reported here.

Keywords

Coumarines, Isoxazoles, Antioxidants, Free Radical.
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  • Synthesis and Antioxidant Potential of Novel 2-Isoxazole Substituted Chromenones Synthesized by Microwave Irradiation

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Authors

Deepti Dongarwar Inamdar
Pharmacy Group, Birla Institute of Technology and Science, Pilani-333031, Rajasthan, India
Afeez M. Dinakaran
Pharmacy Group, Birla Institute of Technology and Science, Pilani-333031, Rajasthan, India
Vadiraj D. Kurdekar
Pharmacy Group, Birla Institute of Technology and Science, Pilani-333031, Rajasthan, India
Hemant R. Jadhav
Pharmacy Group, Birla Institute of Technology and Science, Pilani-333031, Rajasthan, India

Abstract


Novel series of substituted 2-[3-(2,6-halophenyl)-5-methyl-isoxazolyl]-chromen-4-ones were synthesized by microwave irradiation method. The antioxidant activity of the synthesized compounds 5a-j was evaluated using free radical scavenging method (DPPH method) and reducing power assay. The antioxidant activity of synthesized chromenones with respect to the standard used, ascorbic acid is reported here.

Keywords


Coumarines, Isoxazoles, Antioxidants, Free Radical.