Asian Journal of Research in Chemistry

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Synthesis and Biological Screening of Novel Aminoalkyl Substituted Azaphenothiazine


Affiliations
1 Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM University, Kattankulathur-603203, India
     

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Some novel series of alkyl substituted azaphenothiazine were synthesized by condensation of 2-chloro-1-(10H-azaphenothiazin-10yl) ethanone with various amines. The synthesized compounds were confirmed by IR, 1HNMR and Mass spectroscopy.. The bioavailabilities of the compounds were determined by Lipinski rule of 5 using customized software. All the compounds were screened for antimicrobial and sedative activity.

Keywords

Azaphenothiazine, Bioavailability, Antimicrobial Activity, Sedative Activity.
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  • Synthesis and Biological Screening of Novel Aminoalkyl Substituted Azaphenothiazine

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Authors

P. Valentina
Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM University, Kattankulathur-603203, India
K. Ilango
Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM University, Kattankulathur-603203, India
Deepak Jain
Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM University, Kattankulathur-603203, India
Prerna Shukla
Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM University, Kattankulathur-603203, India

Abstract


Some novel series of alkyl substituted azaphenothiazine were synthesized by condensation of 2-chloro-1-(10H-azaphenothiazin-10yl) ethanone with various amines. The synthesized compounds were confirmed by IR, 1HNMR and Mass spectroscopy.. The bioavailabilities of the compounds were determined by Lipinski rule of 5 using customized software. All the compounds were screened for antimicrobial and sedative activity.

Keywords


Azaphenothiazine, Bioavailability, Antimicrobial Activity, Sedative Activity.