Studies of thermal, spectral and antibacterial activities of some inclusion complexes of 4-Thiazolidinone derivatives with β-Cyclodextrin

2-Hydrazinobezothiazole is taken as starting material for the preparation of some compounds of 4-thazolidinone derivative. 4-Thiazolidinone and its analogous are very good pharamacophores performing wide range of biological activities. But the compounds being poor solubility in aqueous medium may be a limiting factor for decreasing their bio-accessibility. To removes the difficulties, its inclusion complexes can be prepared with βcyclodextrin which is non-toxic oligosaccharide. The nature of inclusion complexes along with the compounds characters such as physical, spectral and thermal are discussed. The stoichiometry ratio of 1:1 between the compound and β-cyclodextrin confirmed from their aqueous phase solubility study. The existence of weak intermolecular force between 4-thiazolidinone derivatives and β-cyclodextrin can be ascertained from their thermodynamic stability constants. The antibacterial activity against the microbes like E.coli and S.aureus are susceptible to compounds of 4-thiazolidinone, and it enhances in their corresponding inclusion complexes. The stability of inclusion complex and host–guest relation can be ascertained from thermodynamic parameters along with the free energy change. Besides this, there is alternation in physical and spectral properties of compounds after formation of inclusion complexes.