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Estimation and Validation of Remogliflozin Etabonate in Dosage form and in Bulk Drug by Spectrophotometeric Method


Affiliations
1 Department of Pharmaceutical Chemistry, MMU College of Pharmacy, Ramanagar - 562159 Karnataka, India, India
     

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A simple, sensitive, accurate, rapid and economical Spectrophotometric method was developed for estimation and validation of Remogliflozin Etabonate in pure drug and tablet dosage form. The absorbance was measured at 239.8nm using Ethanol as solvent system. It obeyed Beer’s law at the concentration range of 2-14µg/ml with coefficient of correlation (r2) of 0.997. Limit of detection (LOD) was found to be 1.220µg/ml and Limit of quantitation (LOQ) was found to be 5.220µg/ml. The proposed analytical method was validated according to ICH guidelines, yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness.

Keywords

Remogliflozin Etabonate, Type II diabetes, Spectrophotometry, Ethanol, Method validation
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  • Estimation and Validation of Remogliflozin Etabonate in Dosage form and in Bulk Drug by Spectrophotometeric Method

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Authors

Husnain Fathima
Department of Pharmaceutical Chemistry, MMU College of Pharmacy, Ramanagar - 562159 Karnataka, India, India
Nirmal. T. Havannavar
Department of Pharmaceutical Chemistry, MMU College of Pharmacy, Ramanagar - 562159 Karnataka, India, India
Afnaz Jahan
Department of Pharmaceutical Chemistry, MMU College of Pharmacy, Ramanagar - 562159 Karnataka, India, India

Abstract


A simple, sensitive, accurate, rapid and economical Spectrophotometric method was developed for estimation and validation of Remogliflozin Etabonate in pure drug and tablet dosage form. The absorbance was measured at 239.8nm using Ethanol as solvent system. It obeyed Beer’s law at the concentration range of 2-14µg/ml with coefficient of correlation (r2) of 0.997. Limit of detection (LOD) was found to be 1.220µg/ml and Limit of quantitation (LOQ) was found to be 5.220µg/ml. The proposed analytical method was validated according to ICH guidelines, yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness.

Keywords


Remogliflozin Etabonate, Type II diabetes, Spectrophotometry, Ethanol, Method validation

References