Asian Journal of Research in Chemistry

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Eco-friendly Synthesis of Novel Fluorine Containing 1,3,4-oxadiazoles as Antibacterial and Antifungal Agents


Affiliations
1 Department of Chemistry, Veer Narmad South Gujarat University, Surat -395 007
     

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Title compounds of 1,3,4-oxadiazoles derivatives by the ring closure reaction of m-fluorobenzoic acid hydrazide with an aromatic acid and alumina in presence of POCl3 under microwave irradiation. All the newly synthesized compounds were screened for their antibacterial activity against Gram-positive bacteria namely staphylococcus aureus, Bacillus subtilis and Gram-negative bacteria namely, Escherichia coli and Pseudomonas aeruginosa. All the synthesized compounds were also tested for their antifungal activity against fungi namely, Candida albicans.

Keywords

2,5-disubstituted 1,3,4-oxadiazoles, Ring Closure Reaction, Antibacterial Activity, Antifungal Activity
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  • Eco-friendly Synthesis of Novel Fluorine Containing 1,3,4-oxadiazoles as Antibacterial and Antifungal Agents

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Authors

Ajay N. Mehta
Department of Chemistry, Veer Narmad South Gujarat University, Surat -395 007
Jayraj Yadav
Department of Chemistry, Veer Narmad South Gujarat University, Surat -395 007
K.R. Desai
Department of Chemistry, Veer Narmad South Gujarat University, Surat -395 007

Abstract


Title compounds of 1,3,4-oxadiazoles derivatives by the ring closure reaction of m-fluorobenzoic acid hydrazide with an aromatic acid and alumina in presence of POCl3 under microwave irradiation. All the newly synthesized compounds were screened for their antibacterial activity against Gram-positive bacteria namely staphylococcus aureus, Bacillus subtilis and Gram-negative bacteria namely, Escherichia coli and Pseudomonas aeruginosa. All the synthesized compounds were also tested for their antifungal activity against fungi namely, Candida albicans.

Keywords


2,5-disubstituted 1,3,4-oxadiazoles, Ring Closure Reaction, Antibacterial Activity, Antifungal Activity

References