Asian Journal of Research in Chemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Synthesis of some New Pyrimidines from Chalcone Containing an Imin Group


Affiliations
1 Department of Chemistry, College of Education for Girls, University of Kufa, Najaf, Iraq
     

   Subscribe/Renew Journal


In this present study, p-amino acetophenone condensed with p-nitro benzaldehyde in ethanolic solution of sodium hydroxide to yield corresponding chalcone, which reacts with various aromatic aldehydes in glacial acetic acid to yield corresponding Schiff bases. These chalcones were further reacted with urea, thiourea, guanedin in the presence of base in ethanol, which led to the formation of pyrimidine derivatives. Thin layer chromatography was used to follow the reactions. All the compounds have been characterized by FT-IR Spectroscopy, some of them characterized by (1H - NMR)-spectra and elemental analysis (C.H.N).

Keywords

Synthesis of chalcone, Pyrimidine
Subscription Login to verify subscription
User
Notifications
Font Size


  • Abdullah M. Asiri and Salman A. Khan; (2011)," Synthesis and Anti-Bacterial Activities of a Bis-Chalcone Derived from Thiophene and Its Bis-Cyclized Products", Molecules, 16, 523- 531

  • Rane, R.A.; Telekar, V.N; (2010) "Synthesis and evaluation of novel chloropyrrole molecules designed by molecular hybridization of common pharmacophores as potential antimicrobial agents" . Bioorg. Med. Chem. Lett, 20, 5681-5685.

  • Kumar, D.; Kumar, N.M.; Akamatsu, K.; Kusaka, E.; Harada, H.; Ito, T; (2010) "Synthesis and biological evaluation of indolyl chalcones as antitumor agents". Boorg. Med. Chem. Lett., 20, 3916-3919.

  • Ducki, S.; Forrest, R.; Hadfield, J.A.; Kendall, A.; Lawrence, N.J.; McGown, A.T.; Rennison, D. Potent; (1998) " antimitotic and cell growth inhibitory properties of substituted chalcones". Bioorg. Med. Chem. Lett, 8, 1051-1056.

  • Edenharder, R.; Petersdorff, I.V.; Rauscher, R.; (1993). " Antimutagenic effects of flavoniods, chalcones and structurally related compounds on the activity of 2-amino-3- methylinidazo[4,5-ƒ]quinoline (IQ) and other heterocyclic amine mutagens from cooked food". Mutat. Res., 287, 261-274.

  • P. Prasanna Raja, M.S. Riyazulah, V. Siva Kumar; (2010) "Synthesis and Biological Evaluation of some Chalcone Derivatives". ChemTech Res,2(4)

  • Urmila Gupta, Vineeta Sareen, Vineeta Khatri, Sanjana Chugh,(2005) " Synthesis and antifungal activity of new Fluorine containing 4- (substituted Phenyl azo) Pyrazoles and Isoxazoles", Indian J. of Het.Chem; 14: 265-266

  • Pandey V.K., Gupta V.D. and Tiwari D.N.,(2004) " Synthesis of Substituted Benzoxazines as potential Antiviral agents", Indian J. of Het.Chem., 13, 399-400

  • Solankee. A, Patel. K, and Patel. R. A, (2012) " Facile Synthesis and Studies of Some New Chalcones", E-Journal of Chemistry, 9(4), 1897-1905

  • B. Anupama, Subas Chandra Dinda, Y. Rajendra Prasad and A. Vasudeva Rao, (2012) "Synthesis and antimicrobial Activity of somenew 2,4,6-trisubstituted Pyrimidines", IJRPC, 2(2).

  • M.V. Jyothi, Y. Rajendra Prasda, P. Venkatesh and M. Sureshreddy, (2012) " Synthesis and Antimicrobial Activity of Some Novel Chalcones of 3-Acetyl Pyridine and their Pyrimidine Derivatives", Chem Sci Trans, 1(3), 716-722.


Abstract Views: 749

PDF Views: 2




  • Synthesis of some New Pyrimidines from Chalcone Containing an Imin Group

Abstract Views: 749  |  PDF Views: 2

Authors

Hanan Falih Mohsin
Department of Chemistry, College of Education for Girls, University of Kufa, Najaf, Iraq

Abstract


In this present study, p-amino acetophenone condensed with p-nitro benzaldehyde in ethanolic solution of sodium hydroxide to yield corresponding chalcone, which reacts with various aromatic aldehydes in glacial acetic acid to yield corresponding Schiff bases. These chalcones were further reacted with urea, thiourea, guanedin in the presence of base in ethanol, which led to the formation of pyrimidine derivatives. Thin layer chromatography was used to follow the reactions. All the compounds have been characterized by FT-IR Spectroscopy, some of them characterized by (1H - NMR)-spectra and elemental analysis (C.H.N).

Keywords


Synthesis of chalcone, Pyrimidine

References