Asian Journal of Research in Chemistry

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A typical (3, 5)-thionium-ene-cyclization through Molecular Iodine Catalyzed Convergent Assembly of Tetrahydrothiopyrans


Affiliations
1 Department of Chemistry, Adikavi Nannaya University, Rajahmundry-533105, India
     

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An Iodine catalyzed (3, 5)-thionium-ene-type cyclization for the facile construction of various multisustituted tetrahydrothiopyrans was successfully developed from aldehyde (aromatic and aliphatic) and 6-methylhept-5-en- 2thiol, 6-methyl-2-phenyl hept-5-en-2-thiol and 2, 6-dimethylhept-5-en-2-thiol in the presence of iodine under mild and neutral conditions. This method is simple, convenient and cost-effective.

Keywords

Molecular Iodine, Thionium Ene Reaction, 6-methylhept-5en-2-thiol, 6-methyl-2-phenyl Hept-5-en-2-thiol And 2,6-dimethylhept-5-en-2-thiol, 3-isopropenyl-6-methyl-2phenyltetrahydrothiopyran
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  • A typical (3, 5)-thionium-ene-cyclization through Molecular Iodine Catalyzed Convergent Assembly of Tetrahydrothiopyrans

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Authors

N. Prudhvi Raju
Department of Chemistry, Adikavi Nannaya University, Rajahmundry-533105, India
K. Murali Krishna
Department of Chemistry, Adikavi Nannaya University, Rajahmundry-533105, India
B. Jagan Mohan Reddy
Department of Chemistry, Adikavi Nannaya University, Rajahmundry-533105, India

Abstract


An Iodine catalyzed (3, 5)-thionium-ene-type cyclization for the facile construction of various multisustituted tetrahydrothiopyrans was successfully developed from aldehyde (aromatic and aliphatic) and 6-methylhept-5-en- 2thiol, 6-methyl-2-phenyl hept-5-en-2-thiol and 2, 6-dimethylhept-5-en-2-thiol in the presence of iodine under mild and neutral conditions. This method is simple, convenient and cost-effective.

Keywords


Molecular Iodine, Thionium Ene Reaction, 6-methylhept-5en-2-thiol, 6-methyl-2-phenyl Hept-5-en-2-thiol And 2,6-dimethylhept-5-en-2-thiol, 3-isopropenyl-6-methyl-2phenyltetrahydrothiopyran

References