Asian Journal of Research in Pharmaceutical Sciences

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Development and Validation of Stability Indicating RP-HPLC Method for Piracetam


Affiliations
1 Department of Pharmaceutical Chemistry, MET's Institute of Pharmacy, Bhujbal Knowledge City, Adgaon Nashik, Maharashtra, India
2 Savitribai Phule Pune University, Pune, Maharshtra state, India
     

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A simple, rapid and validated HPLC method was developed for determination of Piracetam in film coated tablets. A Grace C18 (250mm x 4.6ID, Particle size: 5 micron) RP-18 column with a mobile phase consisting of Methanol: Water (20:80v/v) was used. Quantitative evaluation was performed at 205 nm. The HPLC method is selective, precise and accurate and can be used for routine analysis of preparations in pharmaceutical industry quality control laboratories.

Keywords

RP-HPLC, Force Degradation Study, Piracetam.
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  • Development and Validation of Stability Indicating RP-HPLC Method for Piracetam

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Authors

Sushil D. Patil
Department of Pharmaceutical Chemistry, MET's Institute of Pharmacy, Bhujbal Knowledge City, Adgaon Nashik, Maharashtra, India
Prajkta Varpe
Savitribai Phule Pune University, Pune, Maharshtra state, India
Sayali Chaure
Savitribai Phule Pune University, Pune, Maharshtra state, India
Siddharth B. Bhalerao
Savitribai Phule Pune University, Pune, Maharshtra state, India
Sanjay Kshirsagar
Savitribai Phule Pune University, Pune, Maharshtra state, India

Abstract


A simple, rapid and validated HPLC method was developed for determination of Piracetam in film coated tablets. A Grace C18 (250mm x 4.6ID, Particle size: 5 micron) RP-18 column with a mobile phase consisting of Methanol: Water (20:80v/v) was used. Quantitative evaluation was performed at 205 nm. The HPLC method is selective, precise and accurate and can be used for routine analysis of preparations in pharmaceutical industry quality control laboratories.

Keywords


RP-HPLC, Force Degradation Study, Piracetam.

References