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Study of Dengue Fever with Outcome Analysis in Patients with Normal and Abnormal Liver Function Tests


Affiliations
1 GMERS Medical College and Hospital, Sola, India
2 Department of Medicine, GMERS Medical College and Hospital, Sola, India
     

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Background: Study of 100 cases of dengue fever with comparison of outcome in patients with abnormal liver function test v/s normal liver function test.

Methods: An observational and analytical study conducted in GMERS medical college and hospital sola Ahmadabad. 100 adult age 18-75 years patients were included in time period of April, 2014 to April, 2015. Cases of Dengue fever were taken for study presenting with two or more symptoms of dengue fever and positive serology. Routine investigations, liver function tests and ultrasonography of abdomen were carried out. Measurement of outcome with regards to complication, mortality and Length of stay were studied.

Results: Out of 100 patients 60 were Classical DF, 31 DHF and 9 were of DSS. Fever was the most common and Nausea and vomiting was the next common complaint. Significant percentage of Epistaxis and Bleeding were observed in DHF (48.4%) group of patients. Average total bilirubin at presentation was markedly elevated in DSS (2.02±1.38) in comparison to DHF (1.28±1.02) and Classical DF (0.84±1.00) (P<0.05). Average SGPT at presentation was observed to be significantly higher in DSS group (351.38±402.75) followed by DHF (120.56±95.20) and Classical DF (95.40±66.55) group. The difference was statistically significant (P<0.05). Average peak APTT observed to be higher in DSS (44.8±8.2) group followed by DHF (42.2±13.0) and Classical DF (39.6±9.4). SGOT at presentation and the peak value of SGOT with bleeding episodes was observed to be statistically significant. The average length of hospital stay was 5 days. Correlation between average SGOT and average length of stay in the groups with Classical DF and DSS was statistically significant (P<0.05).

Conclusion: Altered liver function test in dengue infection has got effect in terms of length of stay and complications as compared to normal or mild alteration of liver function test. Therefore high SGOT and SGPT can be considered as a prognostic marker of outcome in dengue infection.


Keywords

Dengue Fever, Liver Function, Outcome, Length of Stay, Mortality.
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  • Study of Dengue Fever with Outcome Analysis in Patients with Normal and Abnormal Liver Function Tests

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Authors

M. N. Rangani
GMERS Medical College and Hospital, Sola, India
D. A. Trivedi
GMERS Medical College and Hospital, Sola, India
K. Patel
Department of Medicine, GMERS Medical College and Hospital, Sola, India
R. Patel
GMERS Medical College and Hospital, Sola, India

Abstract


Background: Study of 100 cases of dengue fever with comparison of outcome in patients with abnormal liver function test v/s normal liver function test.

Methods: An observational and analytical study conducted in GMERS medical college and hospital sola Ahmadabad. 100 adult age 18-75 years patients were included in time period of April, 2014 to April, 2015. Cases of Dengue fever were taken for study presenting with two or more symptoms of dengue fever and positive serology. Routine investigations, liver function tests and ultrasonography of abdomen were carried out. Measurement of outcome with regards to complication, mortality and Length of stay were studied.

Results: Out of 100 patients 60 were Classical DF, 31 DHF and 9 were of DSS. Fever was the most common and Nausea and vomiting was the next common complaint. Significant percentage of Epistaxis and Bleeding were observed in DHF (48.4%) group of patients. Average total bilirubin at presentation was markedly elevated in DSS (2.02±1.38) in comparison to DHF (1.28±1.02) and Classical DF (0.84±1.00) (P<0.05). Average SGPT at presentation was observed to be significantly higher in DSS group (351.38±402.75) followed by DHF (120.56±95.20) and Classical DF (95.40±66.55) group. The difference was statistically significant (P<0.05). Average peak APTT observed to be higher in DSS (44.8±8.2) group followed by DHF (42.2±13.0) and Classical DF (39.6±9.4). SGOT at presentation and the peak value of SGOT with bleeding episodes was observed to be statistically significant. The average length of hospital stay was 5 days. Correlation between average SGOT and average length of stay in the groups with Classical DF and DSS was statistically significant (P<0.05).

Conclusion: Altered liver function test in dengue infection has got effect in terms of length of stay and complications as compared to normal or mild alteration of liver function test. Therefore high SGOT and SGPT can be considered as a prognostic marker of outcome in dengue infection.


Keywords


Dengue Fever, Liver Function, Outcome, Length of Stay, Mortality.

References