The Indian Practitioner

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Dapagliflozin and Neuro-Nutrition: A Pragmatic Approach to Manage Diabetic Peripheral Neuropathy


Affiliations
1 President-Medical & Regulatory Affairs, Dept. of Scientific, Aristo Pharmaceuticals Private Limited, Mumbai, India
2 Deputy General Manager-Medical, Dept. of Scientific, Aristo Pharmaceuticals Private Limited, India
3 Assistant General Manager-Medical, Dept. of Scientific, Aristo Pharmaceuticals Private Limited, India
     

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Diabetic peripheral neuropathy (DPN) is the most prevalent microvascular complication of diabetes mellitus. DPN results from a complex interaction of factors including hyperglycemia, glucotoxicity, increased intracellular glucose concentration-induced mitochondrial dysfunction, oxidative stress, etc. A multifaceted approach is warranted for the clinical treatment of DPN. Combination therapy of an antidiabetic agent along with neuro-nutrition aimed at addressing the pathogenic features of neuropathy can be a potential treatment option for effective management of DPN.

Keywords

Type 2 Diabetes (T2DM), Diabetic Peripheral Neuropathy (DPN), Dapagliflozin, Neuro-Nutrition, B-Group Vitamins, Neuroprotection.
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  • Dapagliflozin and Neuro-Nutrition: A Pragmatic Approach to Manage Diabetic Peripheral Neuropathy

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Authors

Manish Maladkar
President-Medical & Regulatory Affairs, Dept. of Scientific, Aristo Pharmaceuticals Private Limited, Mumbai, India
Shrikant Patil
Deputy General Manager-Medical, Dept. of Scientific, Aristo Pharmaceuticals Private Limited, India
Ashok Yadav
Assistant General Manager-Medical, Dept. of Scientific, Aristo Pharmaceuticals Private Limited, India

Abstract


Diabetic peripheral neuropathy (DPN) is the most prevalent microvascular complication of diabetes mellitus. DPN results from a complex interaction of factors including hyperglycemia, glucotoxicity, increased intracellular glucose concentration-induced mitochondrial dysfunction, oxidative stress, etc. A multifaceted approach is warranted for the clinical treatment of DPN. Combination therapy of an antidiabetic agent along with neuro-nutrition aimed at addressing the pathogenic features of neuropathy can be a potential treatment option for effective management of DPN.

Keywords


Type 2 Diabetes (T2DM), Diabetic Peripheral Neuropathy (DPN), Dapagliflozin, Neuro-Nutrition, B-Group Vitamins, Neuroprotection.

References