Progestin as an Inhibitor of Premature Ovulation through LH Suppression in IVF

Progestin is a synthetic form of progesterone hormone. Progestin is used as a contraceptive pill. Progestin can suppress endogenous Luteinizing Hormone (LH) secretion from the pituitary. Premature ovulation in Assisted Reproductive Technology (ART)can be prevented by taking progestin. Progestin–Primed Ovarian Stimulation (PPOS) is now widely used for the treatment of infertility through IVF. Progestin pills are more effective than GnRH analogue for patients. Progestins are an excellent alternative to antagonists. PPOS is slightly more advantageous than the Controlled Ovarian Stimulation (COS) protocol. Progesterone regulates follicular growth through PI3K/AKT and MAPK signaling pathway.