Research Journal of Pharmacology and Pharmacodynamics

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Sleep, Health and Immunocompetence: A Review


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1 KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-10, India
     

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Despite a century of study, we have a very little understanding of why we sleep? And it is most surprising to know that we spend nearly one third of our lives in sleep. Scientists found out another important function for sleep. It actually prepares our emotional brain for next day social and emotional interactions.

Sleep and Immune system are very much related to each other. Generally we feel sleepier when we are suffering from infection and it is believed that sleep deprivation can prone us to more infections. The sleep deprivation causes a lot of irregularities in the levels of cytokines as well as hormones. Are sleep and immune system really related? This is the point to be discussed in this review. To understand this relation a basic study on sleep and immune system components is necessary.


Keywords

NREM Sleep and REM Sleep, Immune System, IL-1β, TNF.
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  • Zimmerman JE, Naidoo N, Raizen DM, Pack AI. Conservation of sleep: insights from non-mammalian model systems. Trends Neurosci. 2008; 31:371-376.

  • Recombinant tumor necrosis factor and interleukin 1 enhance slow-wave sleep. Shoham, S., Davenne, D., Cady, A. B., Dinarello, C. A. and Krueger, J. M Am. J. Physiol. 253, R142-R149 (1987).

  • Krueger JM, Majde JA. Sleep as a host defense: its regulation by microbial products and cytokines. Clin Immunol Immunopathol. 1990;57:188-199.

  • Born, J., Lange, T., Hansen, K., Molle, M. and Fehm, H. L. Effects of sleep and circadian rhythm on human circulating immune cells. J. Immunol. 158, 4454-4464 (1997).

  • Toth, L. A., Tolley, E. A., Broady, R., Blakely, B. and Krueger, J. M. Sleep during experimental trypanosomiasis in rabbits. Proc. Soc. Exp. Biol. Med. 205, 174-181 (1994).

  • Drake, C. L. et al. Effects of an experimentally induced rhinovirus cold on sleep, performance, and daytime alertness. Physiol. Behav. 71, 75-81 (2000).

  • Vitkovic, L., Bockaert, J. and Jacque, C. 'Inflammatory' cytokines: neuromodulators in normal brain? J. Neurochem. 74, 457-471 (2000).

  • Takahashi, S., Kapas, L., Fang, J. and Krueger, J. M. An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits. Brain Res. 690, 241-244 (1995).

  • Opp, M. R., Smith, E. M. and Hughes, T. K. Jr. Interleukin- 10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep. J. Neuroimmunol. 60, 165-168 (1995).

  • Takahashi, S., Kapas, L., Fang, J. and Krueger, J. M. Somnogenic relationships between tumor necrosis factor and interleukin-1. Am. J. Physiol. 276, R1132-R1140 (1999).

  • Kubota, T., Brown, R. A., Fang, J. and Krueger, J. M. Interleukin-15 and interleukin-2 enhance non-REM sleep in rabbits. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281, R1004-R1012 (2001).

  • Kushikata, T., Fang, J. and Krueger, J. M. Interleukin-10 inhibits spontaneous sleep in rabbits. J. Interferon Cytokine Res. 19, 1025-1030 (1999).

  • Hogan, D., Morrow, J. D., Smith, E. M. and Opp, M. R. Interleukin-6 alters sleep of rats. J. Neuroimmunol. 137, 59- 66 (2003).


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  • Sleep, Health and Immunocompetence: A Review

Abstract Views: 356  |  PDF Views: 2

Authors

N. K. D. Devi
KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-10, India
C. Srilatha
KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-10, India
N. Vinisha
KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-10, India
B. S. Mrudula
KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-10, India
B. R. Madhavi
KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-10, India

Abstract


Despite a century of study, we have a very little understanding of why we sleep? And it is most surprising to know that we spend nearly one third of our lives in sleep. Scientists found out another important function for sleep. It actually prepares our emotional brain for next day social and emotional interactions.

Sleep and Immune system are very much related to each other. Generally we feel sleepier when we are suffering from infection and it is believed that sleep deprivation can prone us to more infections. The sleep deprivation causes a lot of irregularities in the levels of cytokines as well as hormones. Are sleep and immune system really related? This is the point to be discussed in this review. To understand this relation a basic study on sleep and immune system components is necessary.


Keywords


NREM Sleep and REM Sleep, Immune System, IL-1β, TNF.

References