Research Journal of Pharmacology and Pharmacodynamics

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Potentiation of Local Anesthetic Activity of Calotropis Gigantea Latex with Epinephrine and pH in Guinea Pig


Affiliations
1 Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., India
     

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The present work describes the potentiation of local anesthetic activity exhibited by milky latex obtained from Calotropis gigantea, with epinephrine and pH. The milky latex at a dilution of 1:10, exhibited significant local anesthetic activity. Both epinephrine (5μg/ml) and pH of 7.2 prolonged the duration of local anesthetic activity. The method used is infiltration anesthesia in Guinea pig. In conclusion, the duration of the effect produced by combination of Calotropis gigantea latex and epinephrine was longer than the combination of latex and pH as well as latex alone.

Keywords

Calotropis Gigantea, Milky Latex, Epinephrine, pH and Infiltration Anesthesia.
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  • Potentiation of Local Anesthetic Activity of Calotropis Gigantea Latex with Epinephrine and pH in Guinea Pig

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Authors

K. K. Rajasekhar
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., India
V. Shankarananth
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., India
C. Sreelakshmi
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., India
A. Sushmitha
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., India
S. Ch. Moulali
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., India
V. Swetha Reddy
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., India

Abstract


The present work describes the potentiation of local anesthetic activity exhibited by milky latex obtained from Calotropis gigantea, with epinephrine and pH. The milky latex at a dilution of 1:10, exhibited significant local anesthetic activity. Both epinephrine (5μg/ml) and pH of 7.2 prolonged the duration of local anesthetic activity. The method used is infiltration anesthesia in Guinea pig. In conclusion, the duration of the effect produced by combination of Calotropis gigantea latex and epinephrine was longer than the combination of latex and pH as well as latex alone.

Keywords


Calotropis Gigantea, Milky Latex, Epinephrine, pH and Infiltration Anesthesia.

References