International Journal of Contemporary Medicine

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A Study of effect of Phenytoin on Liver Enzymes in Epileptic Patients in Western Uttar Pradesh


Affiliations
1 Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, U.P., India
2 Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, U.P., India
     

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Aim & Objective: In this study, we investigated the effects of phenytoin on hepatic enzyme levels in epileptic patients.

Method: In this prospective clinical study, we measured the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT) on 120 epiteptic patients. consecutive admissions to our epilepsy unit.

Result: Serum gamma glutamyl transferase (gammaGT), AST, ALT activities have been estimated in 120 epileptic patients taking Phenytoin as anticonvulsant drugs. Serum AST, ALT & GGT levels were increased.

Conclusion: We found most of our patients on Phenytoin had an elevated serum concentration of GGT, which is consistent with previous reports. AST and ALT were also elevated in these patients and therefore suggested the increased GGT was due to enzyme induction. Elevation of GGT needs to be considered differently in light of the use of new antiepileptic medications.


Keywords

Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Gamma-glutamyl Transpeptidase (GGT), Metabolic Abnormalities, Phenytoin (PHT).
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  • A Study of effect of Phenytoin on Liver Enzymes in Epileptic Patients in Western Uttar Pradesh

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Authors

Harsh Misra
Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, U.P., India
Sunita Singh
Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, U.P., India
Bina Shukla
Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, U.P., India
Yogesh Kumar Rai
Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, U.P., India

Abstract


Aim & Objective: In this study, we investigated the effects of phenytoin on hepatic enzyme levels in epileptic patients.

Method: In this prospective clinical study, we measured the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT) on 120 epiteptic patients. consecutive admissions to our epilepsy unit.

Result: Serum gamma glutamyl transferase (gammaGT), AST, ALT activities have been estimated in 120 epileptic patients taking Phenytoin as anticonvulsant drugs. Serum AST, ALT & GGT levels were increased.

Conclusion: We found most of our patients on Phenytoin had an elevated serum concentration of GGT, which is consistent with previous reports. AST and ALT were also elevated in these patients and therefore suggested the increased GGT was due to enzyme induction. Elevation of GGT needs to be considered differently in light of the use of new antiepileptic medications.


Keywords


Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Gamma-glutamyl Transpeptidase (GGT), Metabolic Abnormalities, Phenytoin (PHT).

References