Toxic effects of Carbaryl on the Vasculature of Liver in Adult Albino Rat, Rattus norvegicus

The excessive use of pesticides and insecticides on agricultural crops, poultry, livestock, home and garden pest control has become one of the major health concerns as humans are exposed to these environment pollutants constantly. Carbaryl, a 1-Naphthyl N-methyl carbamate insecticide has been one of the most commonly and extensively used insecticide in the recent years due to its broad spectrum activity and short residual life on treated crops. However, studies have revealed their presence in the food and fruit products available in the market. Since liver plays an important role in the first pass metabolism of carbaryl, which has seen to cause various disturbances in the liver enzymes, the present work was conducted to study the morphological and morphometric changes in the vasculature of the liver produced by the insecticide carbaryl. Inbred adult Wistar albino rats (150- 200gm) were injected with 200mg/kg body weight of carbaryl intraperitoneally, five days a week for thirty days. Controls were maintained. The animals were group housed with ad libitum access to food and water. The animals were sacrificed within twenty four hours of the last injection, liver was processed and sections (7μ) cut and stained. Microscopic examination revealed a statistically significant dilatation of the hepatic vasculature along with various histomorphological changes in the liver parenchyma.