Role of Azithromycin in Periodontal Diseases

Azithromycin,a macrolide drug has been used for the cure of variety of microbial infections since a significant amount of time. It has been found to possess a far more enhanced performance in discouraging the development of the bacteria than its predecessor drugs like Erythromycin and Clarithromycin. It hasbetter structuraland pharmacokinetic properties which makes it a better version of a azalide drug in terms of itshalf-life,acidstability, durability, intracellular penetrations and anti inflammatoryfunctioning. Having the accessible route of administration it has got a good amount of patient approval. In many cases the recurrence of the infection is common where the antibiotics are not able to reduce the symptoms associated with the disease for a longer period of time. Unlike those medications, Azithromycin focuses solely on the cure and acts as an apt option which puts a brake on the biofilm to mature.In the periodontal context, Azithromycin has especially shown that it prevails at the areas invlolving the pathology. Research has proven that Azithromycin,being the nonessential therapeutic agent for the periodontal wear and tear,has been effortlessly used as a supplement to the non-surgical method for the cure,as it has been challenging to get rid of the debris present in the inaccessible areas. It is also being involved as a mode of therapy in addition to the surgeries involved, it has been able to validate itself in reversing the periodontal conditions for the better. Being administered both in the local and systemic manner,it has been found to be fairly effective in reducing the bleeding on probing,inflammation and tenderness in the gingiva,periodontal pocket depth and the plaque build up.