Research Journal of Pharmacy and Technology

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Novel Approach in Transdermal Drug Delivery System: Transferosome


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1 Nanded Pharmacy College, Opp-Kasturba Matru Seva Kendra, Shyam Nagar, Nanded -431605 Maharashtra, India
     

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Transdermal drug delivery system is emerging system as compared to oral and parenteral. In TDDS, patch system was developed to control the release of drug. Conventional transdermal drug delivery system achieved advantages over the oral and parenteral. Consequently a number of vesicular drug delivery systems such as liposomes, niosomes were been developed as novel transdermal drug delivery system. Firstly, it delivers the drug at a rate directed by the needs of the body, over the period of treatment. Secondly, it channels the active entity to the site of action. Liposomal as well as niosomal systems, are not suitable for transdermal delivery, because of their poor skin permeability, breaking of vesicles, leakage of drug, aggregation, and fusion of vesicles. To overcome these problems, a new type of carrier system called "transfersome", has recently been introduced, which is capable of transdermal delivery of low as well as high molecular weight drugs.Transferosome is a supramolecular entity that can pass through a permeability barrier and there by transport material from the application to the destination site. These are more elastic than standard liposomes. Transferosome has been widely used as a novel carrier for effective transdermal drug delivery. Transferosome enhances the penetration of most of the low as well as high molecular weight drugs, while in case of lipophilic drugs the entrapment efficiency can reach upto 90%. it is now widely used as a novel carrier for both systemic as well as topical delivery of drugs.

Keywords

TDDS, CTDDS, NTDDS, Transfersome,Liposome
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  • Vesicular Approach for Drug Delivery into or Across the Skin: Current Status and Future Prospects. http://priory.com/pharmol/ Manuscript-Jain.htm

  • Brown M, Trayner MJ, Martyyn GP, Akomeah FK. Transdermal drug delivery system, Skin perturbation device. Methods Mol Biol. 437; 2008: 119-39.

  • Li VHK, Robinson JR, Lee VHL. In; Controlled Drug Delivery: Fundamentals and Applications, Marcel Dekker, Inc, New York. 1987; 2nd ed:pp.29: 7.

  • Biju SS, Talegaonkar S, Mishra PR, Khar RK. Vesicular systems: An overview. Indian J Pharm Sci. 68; 2006:141-53.

  • Cevc G, Blume G, Schatzlein A. Transfersome-mediated transepidermal delivery improves the regio-specificity and biological activity of corticosteroids in vivo. J. Control. Release, 45; 1997: 211.

  • Lasch J, Laub P, Wohlrab W. How deep do intact liposomes penetrate to human skin. J. Cont. release. 18; 1991: 55-58.

  • Schatzlein A, Cevc G, Paltauf E. Skin penetration by phospholipids vesicles, Transfersome as visualized by means of the Confocal Scanning Laser Microscopy, In; characterization, metabolism, and novel biological applications. Champaign. AOCS Press, 1995:191-209.

  • Nanda A, Nanda S, Dhall M, Rao R. Transferosome: A Novel Ultradeformable Vesicular Carrier for Transdermal Drug Delivery, Drug Deliv.5(9) ; 2005: 395.

  • http://en.wikipedia.org/wiki/Transfersome

  • Saraf S. Transferosomes: An Overview. Pharmainfo.com. 5(6); 2007: 1329.

  • Jain S, Sapee R, Jain NK. Proultraflexible lipid vesicles for effective transdermal delivery of norgesterol, proceedings of 25th conference of C.R.S., U.S.A., 1998: 32-35.


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  • Novel Approach in Transdermal Drug Delivery System: Transferosome

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Authors

J.S. Pawar
Nanded Pharmacy College, Opp-Kasturba Matru Seva Kendra, Shyam Nagar, Nanded -431605 Maharashtra, India
A. B. Roge
Nanded Pharmacy College, Opp-Kasturba Matru Seva Kendra, Shyam Nagar, Nanded -431605 Maharashtra, India
S. M. Vadvalkar
Nanded Pharmacy College, Opp-Kasturba Matru Seva Kendra, Shyam Nagar, Nanded -431605 Maharashtra, India

Abstract


Transdermal drug delivery system is emerging system as compared to oral and parenteral. In TDDS, patch system was developed to control the release of drug. Conventional transdermal drug delivery system achieved advantages over the oral and parenteral. Consequently a number of vesicular drug delivery systems such as liposomes, niosomes were been developed as novel transdermal drug delivery system. Firstly, it delivers the drug at a rate directed by the needs of the body, over the period of treatment. Secondly, it channels the active entity to the site of action. Liposomal as well as niosomal systems, are not suitable for transdermal delivery, because of their poor skin permeability, breaking of vesicles, leakage of drug, aggregation, and fusion of vesicles. To overcome these problems, a new type of carrier system called "transfersome", has recently been introduced, which is capable of transdermal delivery of low as well as high molecular weight drugs.Transferosome is a supramolecular entity that can pass through a permeability barrier and there by transport material from the application to the destination site. These are more elastic than standard liposomes. Transferosome has been widely used as a novel carrier for effective transdermal drug delivery. Transferosome enhances the penetration of most of the low as well as high molecular weight drugs, while in case of lipophilic drugs the entrapment efficiency can reach upto 90%. it is now widely used as a novel carrier for both systemic as well as topical delivery of drugs.

Keywords


TDDS, CTDDS, NTDDS, Transfersome,Liposome

References